Effect of LoxOralTM and Lactose on In Vitro Dissolution Studies of Progesterone Sustained Release Capsules

Introduction: In vitro drug release and dissolution testing play an important role in pharmaceutical formulation development and quality control. Poorly soluble candidate molecules constitute a major challenge for the formulation development since the insufficient solubility causes problems for in vitro and in vivo assays, with consequent increased risk of attrition and costs (Di et al., 2012), besides low solubility and low dissolution rate often lead to poor bioavailability (Sarnes et al., 2013). The trend in the pharmaceutical industry is to produce more and more compounds that exhibit high lipophilicity and poor water solubility, categorizing into Biopharmaceutical Classification System (BCS) classes II and IV (Vogt et al., 2008).